Pair Name	Bruceine D, Gemcitabine
Disease Info	[ICD-11: 2C10.0]	Pancreatic ductal adenocarcinoma		Investigative
Biological Phenomena	Inhibition-->Cell proliferation
Gene Regulation	Down-regulation	Expression	NFE2L2	hsa4780
	Down-regulation	Expression	KEAP1	hsa9817
	Down-regulation	Expression	HMOX1	hsa3162
	Down-regulation	Expression	NQO1	hsa1728
	Down-regulation	Expression	AKR1B10	KEGG ID N.A.
	Down-regulation	Expression	ABCC1	hsa4363
	Down-regulation	Expression	ABCC5	KEGG ID N.A.
In Vitro Model	PANC-1	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0480
	Capan-2	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0026
	MIA PaCa-2	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0428
In Vivo Model	Capan-2, control non-specific shRNA (shControl) or Nrf2-targeting shRNA (shNrf2)-transfected Miapaca-2 cells (1.5×10⁶ cells/100 μL) were injected into the pancreatic tail of each nude mouse.
Result	Our experimental findings indicate that BD, a potent Nrf2 inhibitor, holds promise for further development into a novel adjuvant therapy for PDAC.